Rita Mora Castro, a brilliant but conflicted lawyer in Mexico, defends a media mogul’s wife in a high-profile case, gaining fame but no satisfaction. An enigmatic cartel leader, Juan “Manitas” Del Monte, later hires her to assist in transitioning to live as Emilia Pérez. Following a secretive journey for surgery, Emilia fakes her death and begins anew. Reuniting with her family under false pretenses sparks tensions, leading to betrayal and a tragic car crash involving Emilia, her ex-wife Jessi, and Jessi’s lover Gustavo. Emilia’s nonprofit legacy inspires a movement for justice, while Rita takes guardianship of Jessi’s children, seeking redemption.